Light micrograph of an esophageal cancer biopsy (thin-section stained at h&e), specifically Infiltrating Keratinizing Well Differentiated Epidermoid Carcinoma. It is a epithelial neoplasic proliferation, constituted by epithelial cell nests, with keratin, and infiltrating in a pattern of solid nests. In the center of these neoplastic epithelial nests there are numerous keratin sheets, some of which become keratin pearls. This indicates a distinct neoplasia of the Keratinizing type. Esophageal cancer is a relatively rare form of cancer. Subtypes: squamous-cell cancer and adenocarcinoma. Causes: tobacco, alcohol and Barrett愀 esophagus. Treatment: surgery, laser therapy, chemotherapy, radiotherapy, radiofrequency ablation. The prognosis is, in general, quite poor because most patients are diagnosed with an advanced stage of the disease. Digital edition. Field of view size: 500 x 740 痠 (0.020 x 0.029 in)