Coloured SPECT (single photon emission computed tomography) anterior (left) and posterior (right) coronal scans of the pelvis of a 70 year old woman with Pagets disease of bone. Pagets disease disrupts the normal cycle of bone renewal, leading to weakened and potentially deformed bones. Here, increased radiotracer uptake (darker area) can be seen in the pelvis due to abnormal and excessive remodelling of the bone, especially on the right iliac wing. The radioactive tracer is technetium 99m-methyl diphosphonate (Tc-99m MDP). The condition typically affects only one or a few bones, most commonly the pelvis, skull, spine, and femur. While many individuals with Pagets disease do not experience symptoms, the changes in bone structure can lead to pain, misshapen bones, and fractures. This condition is rare in individuals under 40 years of age. The exact cause of Pagets disease is unknown, although both environmental and genetic factors are believed to contribute. While there is no cure for the disease, treatments such as bisphosphonates, physiotherapy, and surgery can help alleviate symptoms.